![]() This explains the rationale and ratification of the breast density inform laws in many states in the USA and the introduction of supplemental whole-breast ultrasound (WBUS) screening in Austria. This is crucial, because detection of breast cancer at an early stage substantially improves prognosis, even when using modern therapy regimes. Supplemental ultrasound (US) is an effective imaging method to detect mammography-negative early stage invasive breast cancer in women with heterogeneously and extremely dense breasts, thus reducing the frequency of symptomatic interval carcinomas. A four times higher interval cancer rate is reported for these women compared with women with fatty breasts. In mammographic screening the sensitivity in women with extremely dense breasts is only 61%. Radiologists reading ABUS with CAD software might improve their specificity without losing sensitivity.CAD software for ABUS might prevent non-detection of malignant breast lesions by radiologists.ABUS with CAD software may speed up reading time without compromising radiologists’ accuracy.ConclusionĬAD software for ABUS may decrease the time needed to screen for breast cancer without compromising the screening performance of radiologists. Pooled AUC for CAD-ABUS was comparable with ABUS (0.82 vs. ABUS, respectively, albeit not significantly. Three out of eight readers showed significantly higher specificity using CAD. ![]() RT, sensitivity, specificity, PPV and area under the curve (AUC) were compared. Readers provided a BI-RADS score and a level of suspiciousness (0-100). ![]() Eight radiologists read once with (CAD-ABUS) and once without CAD (ABUS) with > 8 weeks between reading sessions. Unilateral ABUS examinations of 120 women with dense breasts were randomly selected from a multi-institutional archive of cases including 30 malignant (20/30 mammography-occult), 30 benign, and 60 normal cases with histopathological verification or ≥ 2 years of negative follow-up. To determine the effect of computer-aided-detection (CAD) software for automated breast ultrasound (ABUS) on reading time (RT) and performance in screening for breast cancer.
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